首页工具

登录

搜索结果

Search Results for " antipsychotic activity "

36

抑制剂 & 化合物

2

天然产物

如果没找到您满意的产品或者您对产品有其他要求，可以联系我们专业顾问为您提供针对性的合理建议。 QQ咨询网站留言咨询

Cat. No.	Product Name	Target	Signaling Pathways
T25487	Haloperidol decanoate KD 16,KD-136,KD 136,Neoperidole,Haldol	Others	Others
	Haloperidol decanoate (KD 16) 是一种典型的抗精神病药物，用作精神分裂症和情绪障碍的维持治疗，配制成用于肌肉注射的酯。
T5858	Sertindole Lu 23-174,舍吲哚	Dopamine Receptor; 5-HT Receptor; Adrenergic Receptor; Autophagy	Autophagy; GPCR/G Protein; Neuroscience
	Sertindole (Lu 23-174) 是一种非典型抗精神病药，可与多巴胺 D2 受体和血清素受体亚型 5-HT1D、5-HT2A 和 5-HT2C 结合，Kd 值分别为 2.7、20、0.14 和 6 nM。
T28231	Olanzapine N-Oxide	Others	Others
	Olanzapine N-Oxide 是 Olanzapine 的代谢产物，Olanzapine 具有抗精神病活性。
T13620	Clothixamide Clotixamide	Others	Others
	Clothixamide（Clotixamide）是一种噻吨类衍生物，具有抗精神失常活性。
T10989	Dehydroaripiprazole OPC-14857,DM-14857	5-HT Receptor	GPCR/G Protein; Neuroscience
	Dehydroaripiprazole (DM-14857) 是 Aripiprazole 的活性代谢产物，具有抗精神病活性。Aripiprazole 是也一种抗精神病药。
T1740	BD-1047 dihydrobromide BD1047.2HBr	Sigma receptor	GPCR/G Protein
	BD-1047 dihydrobromide (BD1047.2HBr) 是一种选择性的 sigma-1 receptor 受体拮抗剂，在预测精神分裂症疗效的动物模型中具有抗精神病活性。
T28267	ORM-10921 ORM10921,ORM 10921	Adrenergic Receptor	GPCR/G Protein; Neuroscience
	ORM-10921 是一种 α2C-肾上腺素受体拮抗剂，在动物实验中显示出抗精神病和抗抑郁活性。
T0031	Ziprasidone hydrochloride monohydrate 齐拉西酮盐酸盐一水合物,盐酸齐拉西酮水合物,CP 88059	Dopamine Receptor; 5-HT Receptor; Adrenergic Receptor; Norepinephrine; Histamine Receptor	GPCR/G Protein; Immunology/Inflammation; Neuroscience
	Ziprasidone hydrochloride monohydrate (CP 88059) 是一种联合 5-HT（5-羟色胺）和多巴胺受体拮抗剂，具有抗精神病活性的强效作用。它也是去甲肾上腺素再摄取抑制剂。
T20797	NE-100 hydrochloride NE100 Hydrochloride,NE 100 HCl,NE 100 Hydrochloride,NE-100 Hydrochloride,NE-100 HCl	Sigma receptor	GPCR/G Protein
	NE-100 hydrochloride (NE-100 HCl) 是选择性sigma-1 受体拮抗剂，IC50为 4.16 nM。它在体内具有抗精神病活性。它也能抑制内质网应激诱导的海马细胞死亡。
T0031L	Ziprasidone hydrochloride 盐酸齐拉西酮,齐拉西酮盐酸盐,CP-88059 hydrochloride,CP-88059,Ziprasidone HCl	Dopamine Receptor; 5-HT Receptor; Adrenergic Receptor; Norepinephrine; Histamine Receptor	GPCR/G Protein; Immunology/Inflammation; Neuroscience
	Ziprasidone hydrochloride (CP-88059 hydrochloride) 是一种联合 5-HT（5-羟色胺）和多巴胺受体拮抗剂，具有抗精神病活性的强效作用。它也是去甲肾上腺素再摄取抑制剂。
T68047	Clopipazan	Others	Others
	Clopipazan 是一种抗精神病和抗抑郁病化合物。Clopipazan 具有镇静和抗焦虑活性，可能由于选择性阻断某些中间神经元的GABergic发挥作用。
T23854	Carbidine Carbidine dihydrochloride,Karbidin,Carbidin,Karbidine	Others	Others
	Carbidine (Carbidin) 是γ-carboline 的衍生物，一种非典型的抗精神病药物。它可以在体内和体外降低DA 对伏隔核突触体释放3H-DA 和酪氨酸羟化酶活性的抑制作用。
T24885L	Tiaspirone hydrochloride BMY-13859 hydrochloride,Tiaspirone hydrochloride（87691-91-6 Free base)	Dopamine Receptor; 5-HT Receptor	GPCR/G Protein; Neuroscience
	Tiaspirone hydrochloride (BMY-13859 hydrochloride) 具有抗精神病活性。 Tiaspirone hydrochloride 影响大鼠大脑黑质致密带（A9 DA 细胞）和腹侧被盖区（A10 DA 细胞）多巴胺能神经元的电生理活性。
T39211	PD 144418 oxalate	Sigma receptor	GPCR/G Protein
	PD 144418 oxalate is a highly potent and selective sigma 1 (σ1) receptor ligand, displaying a Ki value of 0.08 nM for σ1 and 1377 nM for σ2. It exhibits negligible affinity for other receptors, ion channels, and enzymes. Additionally, PD 144418 oxalate demonstrates potential antipsychotic activity.
T0766	Promazine hydrochloride Romtiazin hydrochloride,Sinophenin hydrochloride,盐酸丙嗪	Dopamine Receptor; 5-HT Receptor; Adrenergic Receptor; AChR	GPCR/G Protein; Neuroscience
	Promazine hydrochloride (Romtiazin hydrochloride) 是一种抗精神病药，也是一种多巴胺受体 (D2) 拮抗剂，能够抑制多巴胺能神经传递。
T0031L2	Ziprasidone 齐拉西酮,Geodon,Zeldox,CP-88059	Dopamine Receptor; 5-HT Receptor; Adrenergic Receptor; Norepinephrine; Histamine Receptor	GPCR/G Protein; Immunology/Inflammation; Neuroscience
	Ziprasidone (Geodon) 是一种联合的 5-HT(5-羟色胺)和多巴胺受体拮抗剂，具有强大的抗精神病活性。它是去甲肾上腺素再摄取抑制剂，对大鼠和人的5-HT1A，5-HT2A 和多巴胺 D2 受体有很高的亲和力。
T23318L	SB 258585	5-HT Receptor	GPCR/G Protein; Neuroscience
	SB 258585 是一种选择性 5-HT6受体拮抗剂。SB 258585 对人重组5-HT6受体的细胞系中的单个受体群体亲和力很高。SB 258585 可用于标记重组和天然5-HT6受体，可用于检测认知增强和抗精神病活性。
T0455	Clozapine 氯氮平,HF 1854,LX 100-129	Dopamine Receptor; Adrenergic Receptor; AChR	GPCR/G Protein; Neuroscience
	Clozapine (HF 1854) 是一种三环二苯二氮卓类药物，属于非典型抗精神病药物。它结合几种类型的中枢神经系统受体，并显示出独特的药理学特征。它是一种血清素拮抗剂，与 5-HT 2A/2C 受体亚型具有强结合力。它还对几种多巴胺能受体表现出很强的亲和力，但对多巴胺 D2 受体仅表现出较弱的拮抗作用，这种受体通常被认为可调节精神抑制活性。
T11435	GlyT1 Inhibitor 1	Others	Others
	GlyT1 Inhibitor 1 is a potent and selective GlyT1 inhibitor (IC50: 38 nM for rGlyT1) with antipsychotic activity.
T21368	Thioproperazine Megeptil,Sulfenazin,Cephalmin,Majeptyl,Vontil,Mazeptyl
	Thioproperazine is a drug with the activity of antipsychotic.
T29009	Trifluoperazine N-Glucuronide
	Trifluoperazine N-Glucuronide is a metabolite of Trifluoperazine with antidepressant and antipsychotic activity.
T26909	Bromerguride
	Bromerguride is a dopamine antagonist with the activity of antipsychotic.
T35307	Zicronapine Lu-31130,Lu31-130,Lu 31130,Lu 31-130,Lu31130,Lu-31-130
	Zicronapine( LU 31-130) is an atypical antipsychotic. Zicronapine has monoaminergic activity and multi-receptor properties. It has shown effective antagonism against dopamine D1, D2, and serotonin 5HT2A receptors in vitro and in vivo.
T16445	PD 144418	Sigma receptor	GPCR/G Protein
	PD 144418 displays potential antipsychotic activity. PD 144418 is a high affinity, potent and selective sigma 1 (σ1) receptor ligand (Ki: 0.08 nM and 1377 nM for σ1 and σ2 respectively). It shows devoid of any significant affinity for other receptors, ion channels, and enzymes.
T13400	Ziprasidone D8 CP-88059 D8	Others	Others
	Ziprasidone D8 is deuterium labeled Ziprasidone, which is a antagonist of combined 5-HT (serotonin) and dopamine receptor and exhibits potent effects of antipsychotic activity.
T39010	Xanomeline tartrate LY 246708 tartrate,Xanomeline tartrate
	Xanomeline (LY 246708), a potent agonist of muscarinic M1/M4 receptors, exhibits antipsychotic-like activity and enhances neuronal excitability. It is a valuable compound for studying schizophrenia.
T15026	Cyamemazine	5-HT Receptor	GPCR/G Protein; Neuroscience
	Cyamemazine, contains the phenothiazine chromophore, is a neuroleptic agent used as an anxiolytic. Cyamemazine is a potent 5-HT3 (Ki: 12 nM), 5-HT2A (Ki: 1.5 nM) and 5-HT2C (Ki: 75 nM) receptors antagonist with antipsychotic activity.
T78514	Timiperone	Dopamine Receptor	GPCR/G Protein; Neuroscience
	Timiperone对大脑多巴胺D2受体显示出高亲和力，具备抗精神病效果，能有效抑制刻板行为。该化合物在精神分裂症研究中可被广泛应用。
T73961	Ziprasidone amino acid
	Ziprasidone amino acid (Ziprasidone Impurity C) 是 Ziprasidone 的杂质。Ziprasidone 是5-HT 和多巴胺 (dopamine receptor) 受体拮抗剂，具有抗精神病活性。
T81336	PZ-1190	Dopamine Receptor	GPCR/G Protein; Neuroscience
	PZ-1190是一种多靶点配体，针对啮齿动物的serotonin和dopamine受体，展现出潜在的抗精神病活性。
T62082	FPPQ
	FPPQ 是一种 5-HT3 和 5-HT6 受体的双重拮抗剂，他们的 Ki 值分别为 0.9 nM 和 3 nM，表现出抗精神病和促认知活性。
T79802	5-HT2C agonist-3	5-HT Receptor	GPCR/G Protein; Neuroscience
	5-HT2C agonist-3 ((+)-19)为高选择性5-HT2C激动剂，其EC50为24 nM，Ki值为78 nM。该化合物表现出抗精神病药物样的活性，并能有效抑制安非他明诱导的多动症。
T38221	N,N-Dipropyldopamine (hydrobromide)
	N,N-Dipropyldopamine is a dopamine receptor agonist.1,2,3 It decreases dihydrophenylalanine (DOPA) levels in the limbic forebrain and striatum of reserpinized rats (ED50s = 25 and 20 μmol/kg, respectively), as well as reduces homovanillic acid levels in rat striatum when administered at a dose of 80 μmol/kg.1 N,N-Dipropyldopamine (0.5-16 mg/kg) reduces spontaneous locomotor activity in mice, an effect that can be reversed by the antipsychotic spiroperidol.2,3
T69129	Clozapine HCl
	Clozapine HCl is a tricylic dibenzodiazepine, classified as an atypical antipsychotic agent. It binds several types of central nervous system receptors, and displays a unique pharmacological profile. Clozapine is a serotonin antagonist, with strong binding to 5-HT 2A/2C receptor subtype. It also displays strong affinity to several dopaminergic receptors, but shows only weak antagonism at the dopamine D2 receptor, a receptor commonly thought to modulate neuroleptic activity. Agranulocytosis is a ...
T79803	5-HT2C agonist-3 free base	5-HT Receptor	GPCR/G Protein; Neuroscience
	5-HT2C agonist-3 ((+)-19) free base 是选择性的5-HT2C激动剂，具EC50: 24 nM及Ki: 78 nM值。该化合物展现出抗精神病药物样活性，并能阻断安非他明引起的多动症。
T61915	Thiethylperazine
	Thiethylperazine 是一种吩噻嗪衍生物。Thiethylperazine 是具有口服活性的组胺H1受体和多巴胺D2受体拮抗剂。Thiethylperazine 也是选择性的ABCC1激活剂，可减少小鼠中的淀粉样 β (Aβ) 负荷。Thiethylperazine 具有抗精神病，止吐和抗菌作用。

化合物

Haloperidol decanoate

Cat.No: T25487

Synonym: KD 16,KD-136,KD 136,Neoperidole,Haldol

Target: Others

Cat.No: T5858

Synonym: Lu 23-174,舍吲哚

Target: Dopamine Receptor, 5-HT Receptor, Adrenergic Receptor, Autophagy

Olanzapine N-Oxide

Cat.No: T28231

Target: Others

Cat.No: T13620

Synonym: Clotixamide

Target: Others

Dehydroaripiprazole

Cat.No: T10989

Synonym: OPC-14857,DM-14857

Target: 5-HT Receptor

BD-1047 dihydrobromide

Cat.No: T1740

Synonym: BD1047.2HBr

Target: Sigma receptor

Cat.No: T28267

Synonym: ORM10921,ORM 10921

Target: Adrenergic Receptor

Ziprasidone hydrochloride monohydrate

Cat.No: T0031

Synonym: 齐拉西酮盐酸盐一水合物,盐酸齐拉西酮水合物,CP 88059

Target: Dopamine Receptor, 5-HT Receptor, Adrenergic Receptor, Norepinephrine, Histamine Receptor

NE-100 hydrochloride

Cat.No: T20797

Synonym: NE100 Hydrochloride,NE 100 HCl,NE 100 Hydrochloride,NE-100 Hydrochloride,NE-100 HCl

Target: Sigma receptor

Ziprasidone hydrochloride

Cat.No: T0031L

Synonym: 盐酸齐拉西酮,齐拉西酮盐酸盐,CP-88059 hydrochloride,CP-88059,Ziprasidone HCl

Target: Dopamine Receptor, 5-HT Receptor, Adrenergic Receptor, Norepinephrine, Histamine Receptor

Cat.No: T68047

Target: Others

Cat.No: T23854

Synonym: Carbidine dihydrochloride,Karbidin,Carbidin,Karbidine

Target: Others

Tiaspirone hydrochloride

Cat.No: T24885L

Synonym: BMY-13859 hydrochloride,Tiaspirone hydrochloride（87691-91-6 Free base)

Target: Dopamine Receptor, 5-HT Receptor

PD 144418 oxalate

Cat.No: T39211

Target: Sigma receptor

Promazine hydrochloride

Cat.No: T0766

Synonym: Romtiazin hydrochloride,Sinophenin hydrochloride,盐酸丙嗪

Target: Dopamine Receptor, 5-HT Receptor, Adrenergic Receptor, AChR

Cat.No: T0031L2

Synonym: 齐拉西酮,Geodon,Zeldox,CP-88059

Target: Dopamine Receptor, 5-HT Receptor, Adrenergic Receptor, Norepinephrine, Histamine Receptor

Cat.No: T23318L

Target: 5-HT Receptor

Cat.No: T0455

Synonym: 氯氮平,HF 1854,LX 100-129

Target: Dopamine Receptor, Adrenergic Receptor, AChR

GlyT1 Inhibitor 1

Cat.No: T11435

Target: Others

Thioproperazine

Cat.No: T21368

Synonym: Megeptil,Sulfenazin,Cephalmin,Majeptyl,Vontil,Mazeptyl

Trifluoperazine N-Glucuronide

Cat.No: T29009

Cat.No: T26909

Cat.No: T35307

Synonym: Lu-31130,Lu31-130,Lu 31130,Lu 31-130,Lu31130,Lu-31-130

Cat.No: T16445

Target: Sigma receptor

Cat.No: T13400

Synonym: CP-88059 D8

Target: Others

Xanomeline tartrate

Cat.No: T39010

Synonym: LY 246708 tartrate,Xanomeline tartrate

Cat.No: T15026

Target: 5-HT Receptor

Cat.No: T78514

Target: Dopamine Receptor

Ziprasidone amino acid

Cat.No: T73961

Cat.No: T81336

Target: Dopamine Receptor

Cat.No: T62082

5-HT2C agonist-3

Cat.No: T79802

Target: 5-HT Receptor

N,N-Dipropyldopamine (hydrobromide)

Cat.No: T38221

Cat.No: T69129

5-HT2C agonist-3 free base

Cat.No: T79803

Target: 5-HT Receptor

Thiethylperazine

Cat.No: T61915

Cat. No.	Product Name	Target	Signaling Pathways
T21855	AMI-193 Espiramida,螺拉米特,Spiramide	Dopamine Receptor; 5-HT Receptor	GPCR/G Protein; Neuroscience
	AMI-193 (Spiramide) 是一种有效和选择性的 5-HT2 和 D2 受体，对 5-HT2、D2 受体、5-HT1A、D1 受体和 5-HT1C 受体的 Kis 分别为 2、3、50、2530 和 4300 nM。 AMI-193 显示出抗精神病活性。
TN2267	Tetrahydroalstonine	Adrenergic Receptor	GPCR/G Protein; Neuroscience
	Tetrahydroalstonine 是从 Rhazya stricta 的果实中提取出来的吲哚类生物碱，是一种具有选择性的 α2-肾上腺素受体拮抗剂。Tetrahydroalstonine 在Rauwolfia tetraphylla 中表现出抗精神病活性。

天然产物

Cat.No: T21855

Synonym: Espiramida,螺拉米特,Spiramide

Target: Dopamine Receptor, 5-HT Receptor

Tetrahydroalstonine

Cat.No: TN2267

Target: Adrenergic Receptor

我们的所有产品和服务仅用于科学研究，不能被用于人体，我们也不向个人提供产品和服务。

Copyright © 2015-2024 TargetMol Chemicals Inc. All rights reserved. 沪ICP备20019793号-4

沪公网安备 31010602006700号

沪公网安备 31010602006700号

TargetMol Loading

联系我们

电话：

400-820-0310

邮箱：

service@tsbiochem.com

QQ：

2881945090（终端用户）

2885109491（经销商）

经销：

终端：

地址：

上海市静安区江场三路238号8楼